Progression of Interstitial Lung Disease in Systemic Sclerosis: The Importance of Pneumoproteins Krebs von den Lungen 6 and CCL18
نویسندگان
چکیده
منابع مشابه
The mucin-1 568 adenosine to guanine polymorphism influences serum Krebs von den Lungen-6 levels.
Krebs von den Lungen (KL)-6 offers a new perspective as a disease marker in pulmonary diseases. The aim of this study was to analyze whether serum KL-6 levels are dependent on the functional adenosine to guanine mucin-1 (MUC1) gene polymorphism at nucleotide position 568 in a well-characterized white population. Polymorphisms were determined in 327 healthy, white individuals and 74 patients wit...
متن کاملSerum CCL18 is predictive for lung disease progression and mortality in systemic sclerosis.
While we accept that there is a group of ILD patients in whom a specific ILD diagnosis is not possible, despite all efforts, we wish to encourage respiratory physicians to pursue an accurate ILD diagnosis, rather than accepting a diagnosis of unclassifiable ILD without full and accurate investigation. Although this is a tempting option, particularly in the absence of ready access to MDD, it is ...
متن کامل- Cerinic Interstitial lung disease in systemic sclerosis
Lung involvement frequently complicates systemic sclerosis (SSc), provoking loss of quality of life and a poor expectation of survival. For this reason an early diagnosis of lung involvement is warranted: high-resolution computed tomography (HRCT), pulmonary function tests (PFT), lung scintigraphy with DTPA and bronchoalveolar lavage (BAL) are mandatory to define and follow-up pulmonary interst...
متن کاملInterstitial lung disease in systemic sclerosis
Systemic sclerosis (SSc) is a connective tissue disease characterised by autoimmune features, widespread vasculopathy and fibrosis of the skin and internal organs. The pattern of internal organ involvement and the natural history of the disease are highly variable. Although the etiology is unknown, most studies point to links between genetic predisposition and environmental factors. SSc has bee...
متن کاملPrognostic Significance of a Tumor Marker Index Based on Preoperative Serum Carcinoembryonic Antigen and Krebs von den Lungen-6 Levels in Non-Small Cell Lung Cancer
Background: We retrospectively analysed the prognostic significance of a tumor marker index (TMI) based on preoperative serum carcinoembryonic antigen (CEA) and Krebs von den Lungen-6 (KL-6) levels in nonsmall cell lung cancer (NSCLC) patients. Materials and Methods: We enrolled 176 NSCLC patients who had preoperative serum CEA and KL-6 level measurements and had undergone curative surgery betw...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arthritis & Rheumatology
سال: 2019
ISSN: 2326-5191,2326-5205
DOI: 10.1002/art.41020